Phenotypic evolution and antigenic drift of h9n2 influenza viruses in

Cited by: 90 articles PMID: Protein Cell , 6 1 , 11 Nov Microb Pathog , , 14 Apr Cited by: 0 articles PMID: Contact us. Europe PMC requires Javascript to function effectively. Recent Activity. Search life-sciences literature Over 39 million articles, preprints and more Search Advanced search. Abstract Available from publisher site using DOI.

A subscription may be required. Search articles by 'Yipeng Sun'. Juan Pu Search articles by 'Juan Pu'. Zhanlei Jiang Search articles by 'Zhanlei Jiang'. Jiang Z ,. Tao Guan Search articles by 'Tao Guan'.

Guan T ,. Yingju Xia Search articles by 'Yingju Xia'. Xia Y ,. Qi Xu Search articles by 'Qi Xu'. Linqing Liu Search articles by 'Linqing Liu'.

Liu L ,. Bo Ma Search articles by 'Bo Ma'. Fulin Tian Search articles by 'Fulin Tian'. Tian F ,. Brown EG ,. Jinhua Liu Search articles by 'Jinhua Liu'. Liu J. Affiliations 1 author 1. Share this article Share with email Share with twitter Share with linkedin Share with facebook. Abstract H9N2 influenza viruses have been circulating in China since , but a systematic investigation of H9N2 in northern China has not been undertaken since Here, using the sequences of 22 viruses we isolated from poultry and pigs in northern China during , in combination with sequences available in a public database, we analyzed the evolution of H9N2 influenza viruses in China from to Our findings demonstrated that the H9N2 viruses in China underwent extensive reassortment, and novel genotypes continued to emerge.

Different epidemiological and biological features among these series were recognized. At least five antigenic groups could be identified over the study period, during which a significant antigenic drift likely occurred between and The continuing evolution of H9N2 influenza viruses in China emphasizes the importance of H9N2 influenza virus surveillance throughout this region to aid pandemic prediction and prevention.

Full text links Read article at publisher's site DOI : Smart citations by scite. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles. Explore citation contexts and check if this article has been supported or disputed. Pathogen change of avian influenza virus in the live poultry market before and after vaccination of poultry in southern China.

Distribution of avian influenza viruses according to environmental surveillance during , China. Reassortment with dominant chicken H9N2 influenza virus contributed to the fifth H7N9 virus human epidemic.

G1-like M and PB2 genes are preferentially incorporated into H7N9 progeny virions during genetic reassortment. Data Data that cites the article This data has been provided by curated databases and other sources that have cited the article.

Go to all records in UniProt. We previously demonstrated that H9N2 subtype avian influenza viruses AIVs isolated from to evolved into distinct antigenic groups C, D, and E and then underwent antigenic drift from commercial vaccines, causing a country-wide outbreak during In this study, H9N2 AIVs isolated from chickens during were antigenically analyzed by performing hemagglutination inhibition and neutralization assays using a panel of polyclonal antibodies.

Our findings confirmed the antigenic drift of recent H9N2 viruses from the commercial vaccine and showed that most of these antigenic variants form a novel HI antigenic group, F, with a few belonging to groups D and E. Slight antigenic variation was observed in group F viruses. Genetic analysis of amino acid sequences deduced from hemagglutinin HA gene sequences indicated that 9 of 15 mutations predominant in the viruses can be mapped to known antigenic sites, which might be responsible for the novel antigenicity of group F.